Recombinant adeno-associated virus (AAV) is the leading vector for gene therapy in the
retina. As non-pathogenic, non-integrating, replication deficient vector, the recombinant virus …

Microglia, the resident immune cells in the retina and nervous system, make irreplaceable
contributions to the maintenance of normal homeostasis and immune surveillance of these …

As one of most common and severe mental disorders, major depressive disorder (MDD)
significantly increases the risks of premature death and other medical conditions for patients …

Unlike in the healthy mammalian retina, macrophages in retinal degenerative states are not
solely comprised of microglia but may include monocyte-derived recruits. Recent studies …

The innate immune system plays key roles in tissue regeneration. For example, microglia
promote neurogenesis in Müller glia in birds and fish after injury. Although mammalian …

Microglia are the main resident immune cells of the nervous system and as such they are
involved in multiple roles ranging from tissue homeostasis to response to insults and circuit …

Traumatic brain injury (TBI) is a serious disease that threatens life and health of people. It
poses a great economic burden on the healthcare system. Thus, seeking effective therapy to …

Microglia are resident central nervous system macrophages and the first responders to
neural injury. Until recently, microglia have been studied only in animal models with …

Despite expressing many key risk genes, the role of microglia in late-onset Alzheimer's
disease pathophysiology is somewhat ambiguous, with various phenotypes reported to be …

Non-neuronal cells are key to the complex cellular interplay that follows central nervous
system insult. To understand this interplay, we generated a single-cell atlas of immune, glial …