The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

All organisms sense and respond to environmental and physiological stress by inducing cell
stress responses that protect core biosynthetic processes such as DNA repair, protein …

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, amyotrophic lateral sclerosis and prion-based neurodegeneration are …

Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is
the most common inherited spinocerebellar ataxia and one of many polyglutamine …

Therapeutic drug development is a long, expensive, and complex process that usually takes
12–15 years. In the early phases of drug discovery, in particular, there is a growing need for …

Age-associated neurodegenerative disorders such as Alzheimer's disease are a major
public health challenge, due to the demographic increase in the proportion of older …

The functional health of the proteome is determined by properties of the proteostasis
network (PN) that regulates protein synthesis, folding, macromolecular assembly …

Ataxia is a neurological disorder characterized by loss of control of body movements.
Spinocerebellar ataxia (SCA), previously known as autosomal dominant cerebellar ataxia, is …

Many neurodegenerative disorders, such as Alzheimer's, Parkinson's and polyglutamine
diseases, share a common pathogenic mechanism: the abnormal accumulation of disease …

The γ-aminobutyric acid–mediated (GABAergic) system participates in many aspects of
organismal physiology and disease, including proteostasis, neuronal dysfunction, and life …