Covalent attachment of myristate and/or palmitate occurs on a wide variety of viral and
cellular proteins. This review will highlight the latest advances in our understanding of the …

As intracellular parasites, viruses rely heavily on the use of numerous cellular machineries
for completion of their replication cycle. The recent discovery of the heterogeneous …

RNA interference (RNAi) is the process by which double-stranded RNA (dsRNA) directs
sequence-specific degradation of messenger RNA in animal and plant cells,. In mammalian …

N-glycosylation of proteins in the endoplasmic reticulum (ER) has a central role in protein
quality control,,. Here we report that N-glycan serves as a signal for degradation by the Skp1 …

The HIV genome encodes a small number of viral proteins (ie, 16), invariably establishing
cooperative associations among HIV proteins and between HIV and host proteins, to invade …

To form an immature HIV-1 capsid, 1,500 HIV-1 Gag (p55) polypeptides must assemble
properly along the host cell plasma membrane. Insect cells and many higher eukaryotic cell …

Mature human immunodeficiency virus type 1 (HIV-1) particles contain a cone-shaped core
structure consisting of the internal ribonucleoprotein complex encased in a proteinaceous …

The Nef protein of the human immunodeficiency virus is a crucial determinant of viral
pathogenesis and disease progression. Nef is abundantly expressed early in infection and …

The human immunodeficiency virus (HIV) protein Nef has been shown to increase the
infectivity of HIV at an early point during infection. Since Nef is known to interact with …

The replication and pathogenicity of lentiviruses is crucially modulated by “auxiliary proteins”
which are expressed in addition to the canonical retroviral ORFs gag, pol, and env …