The maintenance of iron homeostasis is essential for proper cardiac function. A growing
body of evidence suggests that iron imbalance is the common denominator in many …

Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

Iron overload causes progressive organ damage and is associated with arthritis, liver
damage, and heart failure. Elevated iron levels are present in 1%–5% of individuals; …

Iron overload disorders represent a variety of conditions that lead to increased total body
iron stores and resultant end‐organ damage. An elevated ferritin and transferrin‐iron …

The Role of Deferiprone in Iron Chelation | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

The complex pathophysiology in β-thalassemia can translate to multiple morbidities that
affect every organ system. Improved survival due to advances in management means that …

Iron overload is a pathological condition resulting from a congenital impairment of its
regulation, increased intestinal iron absorption secondary to bone marrow erythroid …

Thalassemia syndromes are characterized by the inability to produce normal hemoglobin.
Ineffective erythropoiesis and red cell transfusions are sources of excess iron that the human …

Mitochondria are vital to life and provide biological energy for other organelles and cell
physiological processes. On the mitochondrial double layer membrane, there are a variety of …

Background Mitapivat, an oral activator of pyruvate kinase (PK) in red blood cells (RBCs),
has shown significant improvements in haemoglobin and haemolysis among patients with …