Extensive studies from different fields reveal that many macromolecules, especially
enzymes, show slow transitions among different conformations. This phenomenon is named …

A number of biological systems can be modelled by Markov chains. Recently, there has
been an increasing concern about when biological systems modelled by Markov chains will …

To survive, adapt, and develop, cells respond to external and internal stimuli by tightly
regulating transcription. Transcriptional regulation involves the combinatorial binding of a …

While the analytical solution for the marginal distribution of a stochastic chemical reaction
network has been extensively studied, its joint distribution, ie, the solution of a high …

Abstract Background Rap proteins from Bacilli directly target response regulators of bacterial
two-component systems and modulate their activity. Their effects are controlled by binding of …

Noise-modulating chemicals can synergize with transcriptional activators in reactivating
latent HIV to eliminate latent HIV reservoirs. To understand the underlying biomolecular …

In the work of Amann, Schmiedl and Seifert (2010 J. Chem. Phys. 132 041102), the authors
derived a sufficient criterion to identify a non-equilibrium steady state (NESS) in a three-state …

The inositol trisphosphate receptor (IPR) is a crucial ion channel that regulates the Ca 2+
influx from the endoplasmic reticulum (ER) to the cytoplasm. A thorough study of the IPR …

Reversible chemical modification of enzymes is one of the most important mechanisms in
cellular signaling. We generalize this concept to include cyclic modification of enzyme …

FRET-sensors are a well-established method to investigate protein-protein interactions. To
determine how FRET-sensor can be employed for the study of switchable allosteric …