As the prevalence of obesity continues to rise, the world is facing a major public health
concern. Obesity is a complex disease associated with an increase in several inflammatory …

Introduction Biomarkers can be useful for identifying or ruling out sepsis, identifying patients
who may benefit from specific therapies or assessing the response to therapy. Methods We …

Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate
phosphoribosyltransferase (NAPRT) are two intracellular enzymes that catalyze the first step …

There has been much effort recently to define the role of adipocytokines, which are soluble
mediators derived mainly from adipocytes (fat cells), in the interaction between adipose …

White adipose tissue is no longer considered an inert tissue mainly devoted to energy
storage but is emerging as an active participant in regulating physiologic and pathologic …

Adipocytokines are mainly adipocyte-derived cytokines regulating metabolism and as such
are key regulators of insulin resistance. Some adipocytokines such as adiponectin and …

Intracellular nicotinamide phosphoribosyltransferase (iNampt) is an essential enzyme in the
NAD biosynthetic pathway. An extracellular form of this protein (eNampt) has been reported …

Fat is either white or brown, the latter being found principally in neonates. White fat, which
comprises adipocytes, pre-adipocytes, macrophages, endothelial cells, fibroblasts, and …

White adipose tissue was believed to be just an energy-storage organ, but it is now
recognized to be an active participant in energy homoeostasis and physiological functions …

Aims Visfatin is a novel adipokine whose plasma concentrations are altered in obesity and
obesity-related disorders; these states are associated with an increased incidence of …