Organic compounds labeled with hydrogen isotopes play a crucial role in numerous areas,
from materials science to medicinal chemistry. Indeed, while the replacement of hydrogen by …

The isotopic exchange approach is in use since the first observation of such reactions in
1933 by Lewis. This approach allows the investigation of the pathways of chemical and …

The application of internal standards in quantitative and qualitative bioanalysis is a
commonly used procedure. They are usually isotopically labeled analogs of the analyte …

Selective H/D Exchange at Vinyl and Methylidene Groups with D2O Catalyzed by an Iridium
Complex | Organic Letters ACS ACS Publications C&EN CAS Find my institution Log In Organic …

The catalytic properties of several ruthenium, osmium and rhodium hydride complexes for
hydrogen/deuterium (H/D) exchange between olefins and deuterium oxide (D2O) were …

A simple silver-catalyzed regioselective deuteration of (hetero) arenes and α-deuteration of
2-alkyl azaarenes has been described. This strategy provides an efficient and practical …

Methods to catalytically introduce deuterium in synthetically useful yields ortho to a
carboxylic acid directing group on arenes typically requires D2 or high catalyst loadings …

The purpose of this review is to analyze the different reaction mechanisms of the H/D
exchange on organic substrates catalyzed by transition metal complexes in homogeneous …

An efficient and convenient ruthenium catalysed method for a regiospecific H/D exchange
using D2O is described. Organic moieties such as pyridine, oxazole, imidazole, pyrazole …

We develop a palladium-catalyzed H/D exchange reaction with 8-aminoquinoline as the
directing group as well as D2O as the source of deuterium atom and solvent. This reaction …