AAA ATPase protein–protein interactions as therapeutic targets in cancer
D Mannar, S Ahmed, S Subramaniam - Current Opinion in Cell Biology, 2024 - Elsevier
AAA ATPases are a conserved group of enzymes that couple ATP hydrolysis to diverse
activities critical for cellular homeostasis by targeted protein–protein interactions. Some of …
activities critical for cellular homeostasis by targeted protein–protein interactions. Some of …
[HTML][HTML] Biolayer interferometry and its applications in drug discovery and development
A Jug, T Bratkovič, J Ilaš - TrAC Trends in Analytical Chemistry, 2024 - Elsevier
Biolayer interferometry (BLI) is an optical 'dip-and-read'biosensor method for real-time, label-
free analysis of biomolecular interactions. It can be used for kinetic analyses, analyte …
free analysis of biomolecular interactions. It can be used for kinetic analyses, analyte …
Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection
X Jalencas, H Berg, LO Espeland… - RSC Medicinal …, 2024 - pubs.rsc.org
The EU-OPENSCREEN (EU-OS) European Research Infrastructure Consortium (ERIC) is a
multinational, not-for-profit initiative that integrates high-capacity screening platforms and …
multinational, not-for-profit initiative that integrates high-capacity screening platforms and …
How to Find a Fragment: Methods for Screening and Validation in Fragment‐Based Drug Dscovery
T Kirkman, C dos Santos Silva, M Tosin… - ChemMedChem - Wiley Online Library
Fragment‐based drug discovery (FBDD) is a crucial strategy for developing new drugs that
have been applied to diverse targets, from neglected infectious diseases to cancer. With at …
have been applied to diverse targets, from neglected infectious diseases to cancer. With at …