Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …

The hypothalamic-pituitary-adrenal (HPA) axis is involved in the pathophysiology of many
neuropsychiatric disorders. Increased HPA axis activity can be observed during chronic …

Depression and fatigue are conditions responsible for heavy global societal burden,
especially in patients already suffering from chronic diseases. These symptoms have been …

Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …

This study aimed to investigate the role of baseline levels of peripheral inflammation when
testing the efficacy of antidepressant augmentation with minocycline in patients with …

Despite decades of intensive research, the biological mechanisms that causally underlie
depression are still unclear, and therefore the development of novel effective antidepressant …

The brain-gut axis is a bidirectional communication system between the central nervous
system and the gastrointestinal tract. Serotonin functions as a key neurotransmitter at both …

Accumulating evidence supports an association between depression and inflammatory
processes, a connection that seems to be bidirectional. Clinical trials have indicated …

Psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD) and
schizophrenia, affect a significant percentage of the world population. These disorders are …

The hypothesis of an important role of gut microbiota in the maintenance of physiological
state into the gastrointestinal (GI) system is supported by several studies that have shown a …