Choosing the best genetic strains of mice for developing a new knockout or transgenic
mouse requires extensive knowledge of the endogenous traits of inbred strains. Background …

Rigorous experimental design can minimize the high risk of false positives and false
negatives in the behavioral phenotyping of a new transgenic or knockout mouse. Use of well …

Deficits in social interaction are important early markers for autism and related
neurodevelopmental disorders with strong genetic components. Standardized behavioral …

Dr. Jacqueline N. Crawley, author of the First and Second Editions of What's Wrong with My
Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field calls …

Mouse models of social dysfunction, designed to investigate the complex genetics of social
behaviors, require an objective methodology for scoring social interactions relevant to …

Three defining clinical symptoms of autism are aberrant reciprocal social interactions,
deficits in social communication, and repetitive behaviors, including motor stereotypies and …

Catechol-O-methyltransferase (COMT) is one of the major mammalian enzymes involved in
the metabolic degradation of catecholamines and is considered a candidate for several …

Brain serotonin (5-HT) has been implicated in a number of physiological processes and
pathological conditions. These effects are mediated by at least 14 different 5-HT receptors …

Comprehensive behavioral analyses of transgenic and knockout mice have successfully
identified the functional roles of many genes in the brain. Over the past 10 years, strategies …

Behavioral phenotyping of transgenic and knockout mice requires rigorous, formal analyses.
Well-characterized paradigms can be chosen from the established behavioral neuroscience …