Human umbilical cord mesenchymal stem cells: an overview of their potential in cell-based therapy

T Li, M Xia, Y Gao, Y Chen, Y Xu - Expert opinion on biological …, 2015 - Taylor & Francis
Introduction: Human umbilical cord mesenchymal stem cells (HUC-MSCs) are one of the
typical adult stem cells; they have superiorities including low immunogenicity, non-invasive …

The immunomodulatory function of mesenchymal stem cells: mode of action and pathways

A Uccelli, NK de Rosbo - Annals of the New York Academy of …, 2015 - Wiley Online Library
Mesenchymal stem cells (MSCs) are being increasingly investigated as a therapeutic
alternative, not only for their possible regenerative potential but also for their …

Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study

MEJ Reinders, JW de Fijter, H Roelofs… - Stem cells …, 2013 - academic.oup.com
Despite excellent short-term results, long-term survival of transplanted kidneys has not
improved accordingly. Although alloimmune responses and calcineurin inhibitor-related …

Anti‐donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?

MD Griffin, AE Ryan, S Alagesan… - Immunology and cell …, 2013 - Wiley Online Library
Mesenchymal stem (stromal) cells (MSCs) have potent anti‐inflammatory/
immunosuppressive properties which underlie much of their therapeutic potential. This fact …

Mesenchymal stromal cells in renal transplantation: opportunities and challenges

F Casiraghi, N Perico, M Cortinovis… - Nature Reviews …, 2016 - nature.com
Lifelong immunosuppressive therapy is essential to prevent allograft rejection in transplant
recipients. Long-term, nonspecific immunosuppression can, however, result in life …

Inhibition of B-cell proliferation and antibody production by mesenchymal stromal cells is mediated by T cells

MM Rosado, ME Bernardo, M Scarsella… - Stem cells and …, 2015 - liebertpub.com
Bone marrow (BM)-derived mesenchymal stromal cells (MSCs), endowed with
immunosuppressive and anti-inflammatory properties, represent a promising tool in …

Stem cells: a potential treatment option for kidney diseases

D Liu, F Cheng, S Pan, Z Liu - Stem cell research & therapy, 2020 - Springer
The prevalence of kidney diseases is emerging as a public health problem. Stem cells
(SCs), currently considered as a promising tool for therapeutic application, have aroused …

Conversion of Th17 into IL-17Aneg regulatory T cells: a novel mechanism in prolonged allograft survival promoted by mesenchymal stem cell–supported minimized …

N Obermajer, FC Popp, Y Soeder, J Haarer… - The Journal of …, 2014 - journals.aai.org
The ultimate goal in transplantation medicine is the promotion of operational tolerance.
Although Th cells of the Th17 type have been predominantly associated with rejection of …

Mesenchymal stromal cells and kidney transplantation: pretransplant infusion protects from graft dysfunction while fostering immunoregulation

N Perico, F Casiraghi, E Gotti, M Introna… - Transplant …, 2013 - Wiley Online Library
Bone marrow‐derived mesenchymal stromal cells (MSC) have emerged as useful cell
population for immunomodulation therapy in transplantation. Moving this concept towards …

Current trends and future perspective of mesenchymal stem cells and exosomes in corneal diseases

H Mansoor, HS Ong, AK Riau, TP Stanzel… - International journal of …, 2019 - mdpi.com
The corneal functions (transparency, refractivity and mechanical strength) deteriorate in
many corneal diseases but can be restored after corneal transplantation (penetrating and …