Cells require tight regulation of the intracellular redox balance and consequently of reactive
oxygen species for proper redox signaling and maintenance of metal (eg, of iron and …

A diverse spectrum of vanadium compounds have arisen, over the past years, as potential
therapeutic agents for the treatment of malignancies. Poised to delineate the role of that …

Vanadium compounds exert preventive effects against chemical carcinogenesis on animals,
by modifying, mainly, various xenobiotic enzymes, inhibiting, thus, carcinogen-derived active …

Metals and metal compounds have been used in medicine for several thousands of years. In
this review we summarized the anti-cancer activities of the ten most active metals: arsenic …

Metal complexes are gaining wider applications as enzyme inhibitors for disease treatments.
Factors such as specificity, bioavailability, compensatory effects and complex stability are …

Compounds of the trace element vanadium exert various insulin‐like effects in in vitro and in
vivo systems. These include their ability to improve glucose homeostasis and insulin …

Both environmental exposure to vanadium pentoxide (V 2 O 5, V+ 5 for its ionic
counterparts) and fibroblast senescence are associated with pulmonary fibrosis, but whether …

Summary Saccharomyces WEE1 (Swe1), the only" true" tyrosine kinase in budding yeast, is
an Hsp90 client protein. Here we show that Swe1 Wee1 phosphorylates a conserved …

Compounds of the trace element vanadium have been shown to mimic insulin in in vitro and
in vivo systems. These compounds have been found to exert anti-diabetic effects in rodent …

Most if not all neoplasias show a directly or indirectly deregulated cell cycle. Targeting its
regulatory molecules, the cyclin-dependent kinases, as a therapeutic mode to develop new …