The construction of the blood–brain barrier (BBB), which is a natural barrier for maintaining
brain homeostasis, is the result of a meticulous organisation in space and time of cell–cell …

Microphysiological systems (MPSs), also known as organ-on-a-chip models, aim to
recapitulate the functional components of human tissues or organs in vitro. Over the last …

Background In ischemic stroke, the function of the cerebral vasculature is impaired. This
vascular structure is formed by the so-called neurovascular unit (NVU). A better …

Since the outbreak of the global pandemic caused by severe acute respiratory coronavirus 2
(SARS-CoV-2), several clinical aspects of the disease have come into attention. Besides its …

The blood-brain barrier (BBB) is a highly selective barrier that ensures a homeostatic
environment for the central nervous system (CNS). BBB dysfunction, inflammation, and …

At the moment, anaplastic changes within the brain are challenging due to the complexity of
neural tissue, leading to the inefficiency of therapeutic protocols. The existence of a cellular …

The estrogen receptor (ER) designated ERα has actions in many cell and tissue types that
impact glucose homeostasis. It is unknown if these include mechanisms in endothelial cells …

Central nervous system (CNS) disorders represent one of the leading causes of global
health burden. Nonetheless, new therapies approved against these disorders are among …

Nonviral nanoparticles have emerged as an attractive alternative to viral vectors for gene
therapy applications, utilizing a range of lipid‐based, polymeric, and inorganic materials …

Significant advancements in the field of preclinical in vitro blood-brain barrier (BBB) models
have been achieved in recent years, by developing monolayer-based culture systems …