Ulcerative colitis (UC) is one of the most common forms of inflammatory bowel disease (IBD)
characterized by inflammation of the mucosal layer of the colon. Diagnosis of UC is based …

Introduction Acute severe ulcerative colitis (ASUC) is a severe manifestation of ulcerative
colitis (UC) that warrants hospitalisation. Despite significant advances in therapeutic options …

Background T helper (T h) and regulatory T (T reg) cell-related cytokines are implicated in
inflammatory bowel diseases, including ulcerative colitis (UC). While these cytokines are …

Background and Aims: AVX-470 is an orally administered, bovine-derived, anti-tumour
necrosis factor (TNF) antibody with local activity in the gastrointestinal tract. In the first-in …

Eosinophilic esophagitis (EoE) is an emerging allergic, IgE‐and non‐IgE (Th2 cell)‐
mediated disease. There are major gaps in the understanding of the basic mechanisms that …

Several endoscopic indices, clinical activity indices, patient-reported outcomes, and
histologic indices are used to evaluate disease activity in UC. However, their operating …

Background Patients with ulcerative colitis (UC) are at risk for colorectal neoplasia.
Challenges associated with surveillance colonoscopy with random biopsies for detection of …

Background The ability to measure the expression of proinflammatory cytokines from
intestinal biopsies in patients with Crohn's disease in an accurate and reproducible way is …

Ulcerative colitis (UC) is one of the most common forms of inflammatory bowel disease (IBD)
characterized by inflammation of the mucosal layer of the colon. Diagnosis of UC is based …

The conventional drug development paradigm consists of a rigorous step-wise process that
takes place over many years. Although this approach results in access to safe and effective …