[HTML][HTML] Oxidative stress: a key modulator in neurodegenerative diseases

A Singh, R Kukreti, L Saso, S Kukreti - Molecules, 2019 - mdpi.com
Oxidative stress is proposed as a regulatory element in ageing and various neurological
disorders. The excess of oxidants causes a reduction of antioxidants, which in turn produce …

Inflammation in CNS neurodegenerative diseases

J Stephenson, E Nutma, P van der Valk, S Amor - Immunology, 2018 - Wiley Online Library
Neurodegenerative diseases, the leading cause of morbidity and disability, are gaining
increased attention as they impose a considerable socioeconomic impact, due in part to the …

Selective vulnerability in neurodegenerative diseases

H Fu, J Hardy, KE Duff - Nature neuroscience, 2018 - nature.com
Neurodegenerative diseases have two general characteristics that are so fundamental we
usually take them for granted. The first is that the pathology associated with the disease only …

[HTML][HTML] In vitro Models of Neurodegenerative Diseases

A Slanzi, G Iannoto, B Rossi, E Zenaro… - Frontiers in cell and …, 2020 - frontiersin.org
Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …

Mitochondrial dysfunction in the development and progression of neurodegenerative diseases

J Johnson, E Mercado-Ayon, Y Mercado-Ayon… - Archives of biochemistry …, 2021 - Elsevier
In addition to ATP synthesis, mitochondria are highly dynamic organelles that modulate
apoptosis, ferroptosis, and inflammasome activation. Through executing these varied …

Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics

A Akhtar, A Andleeb, TS Waris, M Bazzar… - Journal of controlled …, 2021 - Elsevier
The central nervous system (CNS) encompasses the brain and spinal cord and is
considered the processing center and the most vital part of human body. The central …

Apoptosis and its therapeutic implications in neurodegenerative diseases

NS Erekat - Clinical Anatomy, 2022 - Wiley Online Library
Neurodegenerative disorders are characterized by progressive loss of particular populations
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …

[HTML][HTML] Programmed cell death in diabetic nephropathy: a review of apoptosis, autophagy, and necroptosis

NS Erekat - Medical Science Monitor: International Medical Journal …, 2022 - ncbi.nlm.nih.gov
Diabetic nephropathy is a common complication of type I and type II diabetes, in which renal
glomeruli are destroyed, resulting in renal damage, proteinuria, and hypertension …

[HTML][HTML] Role of SNAREs in neurodegenerative diseases

A Margiotta - Cells, 2021 - mdpi.com
Neurodegenerative diseases are pathologies of the central and peripheral nervous systems
characterized by loss of brain functions and problems in movement which occur due to the …

[HTML][HTML] Research progress on multiple cell death pathways of podocytes in diabetic kidney disease

C Yang, Z Zhang, J Liu, P Chen, J Li, H Shu, Y Chu… - Molecular …, 2023 - Springer
Diabetic kidney disease (DKD) is the main cause of end-stage renal disease, and its clinical
manifestations are progressive proteinuria, decreased glomerular filtration rate, and renal …