Because of adverse reactions, early efforts to introduce high affinity competitive or use-
dependent NMDA receptor antagonists into patients suffering from stroke, head trauma or …

Glutamate neurotoxicity has been implicated in stroke, head trauma, multiple sclerosis and
neurodegenerative diseases. Although recent data show that cultured glioma cells secrete …

Multitarget drugs have been to be found effective in controlling complex diseases. However,
how to design multitarget drugs presents a great challenge. We have developed a computer …

There are many examples of compounds showing neuroprotective efficacy in animal models
of stroke but not in clinical trials. It is possible that some or all of these compounds possess …

Over the last 20 years, the impact of imaging on the clinical sciences is unquestionable. It
has revolutionized the diagnosis and treatment of disease. Interestingly, the use of imaging …

Glutamate is an essential neurotransmitter in the CNS. However, at abnormally high
concentrations it becomes cytotoxic. Recent studies in our laboratory showed that glutamate …

Выраженность когнитивных нарушений при сосудистом поражении головного мозга
варьирует от минимальных расстройств до деменции и определяется целым рядом до …

Данные о распространенности сосудистой деменции носят приблизительный
характер. Цифры, которые приводятся в литературе, получены преимущественно в …

The success of the low affinity use-dependent NMDA receptor antagonists to reach clinical
trials can be readily attributed to their wider margins of safety and lack of neurotoxicity at …

We have revealed previously that the survival rate of β cells of cat retinal ganglion cells
(RGCs) rapidly decreased to 29% on day 7 after optic nerve transection, whereas that of α …