Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

Atrial fibrillation (AF) is a very common cardiac arrhythmia with an estimated prevalence of
33.5 million patients globally. It is associated with an increased risk of death, stroke and …

Flecainide suppresses cardiac tachyarrhythmias including paroxysmal atrial fibrillation,
supraventricular tachycardia and arrhythmic long QT syndromes (LQTS), as well as the …

The mouse is the second mammalian species, after the human, in which substantial amount
of the genomic information has been analyzed. With advances in transgenic technology …

Diabetic cardiomyopathy is defined as the myocardial dysfunction that suffers patients with
diabetes mellitus (DM) in the absence of hypertension and structural heart diseases such as …

Background: This study examined the clinical characteristics, genetic basis, healthcare
utilisation and costs of catecholaminergic ventricular tachycardia (CPVT) patients from a …

Skeletal and cardiac muscle excitation–contraction coupling commences with Nav1. 4/Nav1.
5-mediated, surface and transverse (T-) tubular, action potential generation. This initiates …

Cardiac ryanodine receptor (RyR2) mutations are implicated in the potentially fatal
catecholaminergic polymorphic ventricular tachycardia (CPVT) and in atrial fibrillation. CPVT …

Voltage-dependent Na+ channel activation underlies action potential generation
fundamental to cellular excitability. In skeletal and cardiac muscle this triggers contraction …