Four adenosine receptors have been cloned and characterized from several mammalian
species. The receptors are named adenosine A1, A2A, A2B, and A3. The A2A and A2B …

▪ Abstract Adenosine is a modulator that has a pervasive and generally inhibitory effect on
neuronal activity. Tonic activation of adenosine receptors by adenosine that is normally …

Adenosine has several functions within the CNS that involve an inhibitory tone of
neurotransmission and neuroprotective actions in pathological conditions. The …

Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic
modulator and also as a neuromodulator at the synaptic level. We will present evidence to …

The dense network of capillaries composed of capillary endothelial cells (cECs) and
pericytes lies in close proximity to all neurons, ideally positioning it to sense neuron-and …

Adenosine accumulation during ischemia and inflammation protects tissues from injury. In
ischemic tissues adenosine accumulates due to inhibition of adenosine kinase, and in …

Ischemia is a multifactorial pathology characterized by different events evolving in the time.
After ischemia a primary damage due to the early massive increase of extracellular …

Interest is growing in the role of adenosine triphosphate (ATP) on P2 receptors during
hypoxic/ischemic events in the brain. However, there is no direct evidence of an increase in …

Eighty years ago Drury & Szent-Gyorgyi described the actions of adenosine, AMP (adenylic
acid) and ATP (pyrophosphoric or diphosphoric ester of adenylic acid) on the mammalian …

Now there is general agreement that the purine nucleoside adenosine is an important
neuromodulator in the central nervous system, playing a crucial role in neuronal excitability …