The clinical responses observed following treatment with immune checkpoint inhibitors
(ICIs) support immunotherapy as a potential anticancer treatment. However, a large …

Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …

Neutrophils are the most abundant myeloid cells in human blood and are emerging as
important regulators of cancer. However, their functional importance has often been …

Neutrophils are major effectors and regulators of the immune system. They play critical roles
not only in the eradication of pathogens but also in cancer initiation and progression …

Macrophages phagocytize pathogens to initiate innate immunity and products from the
tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-associated …

Structured models of ontogenic, phenotypic and functional diversity have been instrumental
for a renewed understanding of the biology of immune cells, such as macrophages and …

Monocytes and macrophages are central players of the innate immune response and play a
pivotal role in the regulation of inflammation. Thereby, they actively participate in all phases …

Metastatic disease is responsible for approximately 90% of cancer deaths. For successful
dissemination and metastasis, cancer cells must evade detection and destruction by the …

Tumor-promoting inflammation and the avoidance of immune destruction are hallmarks of
cancer. While innate immune cells, such as neutrophils, monocytes, and macrophages, are …