Phosphate is an essential macronutrient for fungal proliferation as well as a key mediator of
antagonistic, beneficial, and pathogenic interactions between fungi and other organisms. In …

Protein synthesis is an energetically costly cellular activity. It is therefore important that the
process of mRNA translation remains in excellent synchrony with cellular metabolism and its …

The ability to independently control the expression of different genes is important for
quantitative biology. Using budding yeast, we characterize GAL1pr, GALL, MET3pr, CUP1pr …

Caloric restriction (CR) is known to extend life span across species; however, the molecular
mechanisms are not well understood. We investigate the mechanism by which glucose …

Background The lack of energy-protein intake has been shown to increase the risk of
stunting in under-five children. The quality of protein in food is assessed by the …

Cells must appropriately sense and integrate multiple metabolic resources to commit to
proliferation. Here, we report that S. cerevisiae cells regulate carbon and nitrogen metabolic …

Methionine restriction (MR) provides metabolic benefits in many organisms. However,
mechanisms underlying the MR-induced effect remain incompletely understood. Here, we …

Solute carriers (SLCs) are the largest family of transmembrane transporters in the human
genome with more than 400 members. Despite the fact that SLCs mediate critical biological …

Skeletal muscle has a remarkable capacity to regenerate following injury, a property
conferred by a resident population of muscle stem cells (MuSCs). In response to injury …

Studies using a fungal model, Saccharomyces cerevisiae, have been instrumental in
advancing our understanding of sulfur metabolism in eukaryotes. Sulfur metabolites …