ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities

N Zamorano Cuervo, N Grandvaux - elife, 2020 - elifesciences.org
Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with …

[HTML][HTML] IL-6: Relevance for immunopathology of SARS-CoV-2

EO Gubernatorova, EA Gorshkova, AI Polinova… - Cytokine & growth factor …, 2020 - Elsevier
COVID-19 mortality is strongly associated with the development of severe pneumonia and
acute respiratory distress syndrome with the worst outcome resulting in cytokine release …

[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Role of the ACE2/angiotensin 1–7 axis of the renin–angiotensin system in heart failure

VB Patel, JC Zhong, MB Grant, GY Oudit - Circulation research, 2016 - Am Heart Assoc
Heart failure (HF) remains the most common cause of death and disability, and a major
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …

The vasoprotective axes of the renin-angiotensin system: physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases

XC Li, J Zhang, JL Zhuo - Pharmacological research, 2017 - Elsevier
The renin-angiotensin system (RAS) is undisputedly one of the most prominent endocrine
(tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) vasoactive …

Angiotensin‐converting enzyme 2 (ACE2) is a key modulator of the renin angiotensin system in health and disease

C Tikellis, MC Thomas - International journal of peptides, 2012 - Wiley Online Library
Angiotensin‐converting enzyme 2 (ACE2) shares some homology with angiotensin‐
converting enzyme (ACE) but is not inhibited by ACE inhibitors. The main role of ACE2 is the …

Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets

F Jiang, J Yang, Y Zhang, M Dong, S Wang… - Nature Reviews …, 2014 - nature.com
The renin–angiotensin system (RAS) has pivotal roles in the regulation of normal physiology
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …

ACE2 in the era of SARS-CoV-2: controversies and novel perspectives

F Saponaro, G Rutigliano, S Sestito… - Frontiers in Molecular …, 2020 - frontiersin.org
Angiotensin-converting enzyme 2 (ACE2) is related to ACE but turned out to counteract
several pathophysiological actions of ACE. ACE2 exerts antihypertensive and …

Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transporters

K Kuba, Y Imai, T Ohto-Nakanishi… - Pharmacology & …, 2010 - Elsevier
Angiotensin-converting enzyme (ACE) 2 is a homolog to the carboxypeptidase ACE, which
generates angiotensin II, the main active peptide of renin–angiotensin system (RAS). After …

Angiotensin II mediates angiotensin converting enzyme type 2 internalization and degradation through an angiotensin ii type i receptor–dependent mechanism

MR Deshotels, H Xia, S Sriramula, E Lazartigues… - …, 2014 - Am Heart Assoc
Angiotensin-converting enzyme type 2 (ACE2) is a pivotal component of the renin–
angiotensin system, promoting the conversion of angiotensin II (Ang-II) to Ang-(1-7). We …