The ATP‐binding cassette (ABC) transporter superfamily comprises membrane proteins that
efflux various substrates across extra‐and intracellular membranes. Mutations in ABC genes …

In most organisms, ABC transporters constitute one of the largest families of membrane
proteins. In humans, their functions are diverse and underpin numerous key physiological …

Mitochondria provide chemical energy for endoergonic reactions in the form of ATP, and
their activity must meet cellular energy requirements, but the mechanisms that link organelle …

The heme-regulated kinase HRI is activated under heme/iron deficient conditions; however,
the underlying molecular mechanism is incompletely understood. Here, we show that iron …

Members of the mitochondrial carrier family (SLC25) transport a variety of compounds
across the inner membrane of mitochondria. These transport steps provide building blocks …

ATP-binding cassette (ABC) transporters are found in all domains of life and constitute one
of the largest protein superfamilies. ABC transporters harness the energy of ATP binding …

BACKGROUND A new generation of more active succinate dehydrogenase (Sdh) inhibitors
(SDHIs) is currently widely used to control Septoria leaf blotch in northwest Europe. Detailed …

Synthesis of iron-sulfur (Fe/S) clusters in living cells requires scaffold proteins for both facile
synthesis and subsequent transfer of clusters to target apoproteins. The human …

ABC transporters fulfill diverse physiological functions in different cellular localizations
ranging from the plasma membrane to intracellular membranous compartments. Several …

ABSTRACT Iron-sulfur (Fe-S) clusters are ubiquitous inorganic cofactors required for
numerous essential cellular pathways. Since they cannot be scavenged from the …