Aging is a complex process with an impact on essentially all organs. Declined cellular repair
causes increased damage at genomic and proteomic levels upon aging. This can lead to …

Objective Pembrolizumab has become an integral first line therapeutic agent for non-small
cell lung cancer (NSCLC), but its potential predictive role in clinical and molecular …

Scope Akkermansia muciniphila (A. muciniphila) is an intestinal commensal with anti‐
inflammatory properties both in the intestine and other organs. The aim is to investigate the …

Gut microbiota has been identified as a key player in the development of alcoholic liver
disease (ALD). Targeting gut microbiota with probiotic intervention will be an attractive …

Although it is clear that probiotics improve intestinal barrier function, little is known about the
effects of probiotics on the aging intestine. We investigated effects of 10-week bacterial …

Scope Akkermansia muciniphila (A. muciniphila) are Gram negative commensal bacteria,
degrading mucin in the intestinal mucosa, modulating intestinal permeability and …

Objectives. Despite the fact that it is widely acknowledged that immune checkpoint inhibitors
(ICIs) rely on the presence of immune response to take their antitumor effect, little is known …

Introduction The mechanisms underlying innate immune memory (trained immunity)
comprise epigenetic reprogramming of transcriptional pathways associated with alterations …

The initial exposure to pathogens and commensals confers innate immune cells the capacity
to respond distinctively upon a second stimulus. This training capacity might play key …

Probiotics such as L. plantarum WCFS1 can modulate immune responses in healthy
subjects but how this occurs is still largely unknown. Immune-sampling in the Peyer Patches …