Shedding light on thyroid hormone disorders and Parkinson disease pathology: mechanisms and risk factors

S Mohammadi, M Dolatshahi, F Rahmani - Journal of Endocrinological …, 2021 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of
dopaminergic neurons. Dopaminergic system is interconnected with the hypothalamic …

Receptor modulators associated with the hypothalamus-pituitary-thyroid axis

X Cheng, H Zhang, S Guan, Q Zhao… - Frontiers in …, 2023 - frontiersin.org
The hypothalamus-pituitary-thyroid (HPT) axis maintains normal metabolic balance and
homeostasis in the human body through positive and negative feedback regulation. Its main …

A scientometric analysis and visualization of research on Parkinson's disease associated with pesticide exposure

C Liu, Z Liu, Z Zhang, Y Li, R Fang, F Li… - Frontiers in Public …, 2020 - frontiersin.org
The etiology and pathogenesis of Parkinson's disease (PD) have not yet been clearly
described. Both genetic and environmental factors contribute to the onset and progression of …

Contra-directional expression of plasma superoxide dismutase with lipoprotein cholesterol and high-sensitivity C-reactive protein as important markers of Parkinson's …

W Yang, Z Chang, R Que, G Weng, B Deng… - Frontiers in aging …, 2020 - frontiersin.org
Aim: Oxidative stress and inflammation play critical roles in the neuropathogenesis of PD.
We aimed to evaluate oxidative stress and inflammation status by measuring serum …

Morin ameliorates rotenone-induced Parkinson disease in mice through antioxidation and anti-neuroinflammation: gut-brain axis involvement

IO Ishola, IO Awogbindin, TG Olubodun-Obadun… - Brain Research, 2022 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting
both motor and non-motor functions. It is well reported that the neuropathological process …

Screening of Monoamine Oxidase B Inhibitors from Fragaria nubicola by Ligand Fishing and Their Neuroprotective Effects

YK Hu, YM Liu, XL Bai, C Ma, X Liao - Journal of Agricultural and …, 2022 - ACS Publications
Fragaria nubicola, known as Tibetan strawberry, is an edible plant possessing various
health-promoting effects. However, its functional compositions were rarely studied. In this …

[HTML][HTML] Improvement of non-motor and motor behavioral alterations associated with Parkinson-like disease in Drosophila melanogaster: Comparative effects of …

MR Poetini, EAS Musachio, SM Araujo, VC Bortolotto… - NeuroToxicology, 2022 - Elsevier
Non-motor alterations such as anxiety and memory deficit may represent early indications of
Parkinson's disease (PD), and therapeutic strategies that reduce non-motor alterations are …

Legumain knockout improved cognitive impairment via reducing neuroinflammation in right unilateral common carotid artery occlusion mice

X Chai, X Li, W Zhang, X Tan, H Wang, Z Yang - Life sciences, 2021 - Elsevier
Aims Chronic cerebral hypoperfusion (CCH) is a state of chronic cerebral blood flow
reduction, and it is the main cause of cognitive impairment and neurodegenerative diseases …

Biochemical and physiological insights into TRH receptor-mediated signaling

R Trubacova, Z Drastichova, J Novotny - Frontiers in Cell and …, 2022 - frontiersin.org
Thyrotropin-releasing hormone (TRH) is an important endocrine agent that regulates the
function of cells in the anterior pituitary and the central and peripheral nervous systems. By …

Target enzymes considered for the treatment of Alzheimer's disease and Parkinson's disease

N Kim, HJ Lee - BioMed Research International, 2020 - Wiley Online Library
Various amyloidogenic proteins have been suggested to be involved in the onset and
progression of neurodegenerative diseases (ND) such as Alzheimer's disease (AD) and …