Coumarins belong to the benzopyrone family commonly found in many medicinal plants.
Natural coumarins demonstrated a wide spectrum of pharmacological activities, including …

The purpose of this document is to update the “2014 AHA/ACC/HRS Guideline for the
Management of Patients With Atrial Fibrillation” S1. 3-1 (2014 AF Guideline) in areas for …

The current manuscript is the second update of the original Practical Guide, published in
2013 [Heidbuchel et al. European Heart Rhythm Association Practical Guide on the use of …

Background and Purpose—This ARISTOPHANES study (Anticoagulants for Reduction in
Stroke: Observational Pooled Analysis on Health Outcomes and Experience of Patients) …

Background Hypercoagulability and thromboembolism are prominent features of severe
COVID‐19, and ongoing anticoagulant use might be protective. Methods We conducted a …

Background: Gastrointestinal bleeding (GIB) rates for direct oral anticoagulants (DOACs)
and warfarin have been extensively compared. However, population-based studies …

Millions of individuals in the United States require long-term treatment with an oral
anticoagulant. For decades, vitamin K antagonists were the only oral option available; …

Over the past decade, pharmacogenetic testing has emerged in clinical practice to guide
selected cardiovascular therapies. The most common implementation in practice is …

Background and Purpose—Limited evidence exists on the effectiveness and safety of
warfarin and all 4 available non-vitamin K antagonist oral anticoagulants (NOACs) from …

Atrial fibrillation (AF) and venous thromboembolism (VTE) are highly prevalent conditions
with a significant healthcare burden, and represent the main indications for anticoagulation …