Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that effects 50 million
people worldwide. In this review, AD pathology and the development of novel therapeutic …

This article provides an overview of compounds based on imidazo [1, 2-a] pyridine, imidazo
[1, 5-a] pyridine, imidazo [4, 5-b] pyridine and imidazo [4, 5-c] pyridine scaffolds, which act as …

Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …

A silver‐catalyzed protocol for the synthesis of 3‐(1H‐isochromen)‐chromones is described.
The method involves an initial 6‐endo‐dig cyclization of o‐alkynylbenzaldehydes and …

Alzheimer's disease (AD) is a major progressive and perplexing cortical degenerative
disease of the brain in the elderly. It contributes to a significant socioeconomic burden on …

Alzheimer's disease (AD) is a neurodegenerative disorder known for the presence of
amyloid beta plaques resulting from the sequential action of β-secretase and γ-secretase on …

Coumarins are the phytochemicals, which belong to the family of benzopyrone, that display
interesting pharmacological properties. Several natural, synthetic and semisynthetic …

Alzheimer's disease (AD) is a complex neurological disorder with diverse underlying
pathological processes. Several lines of evidence suggest that BACE1 is a key enzyme in …

Efficacious protocols have been established to synthesize a structurally privileged Π-
extended coumarin-fused pyridone nucleus by activating the vinylic C (sp2)–H bond of …

Due to the hugely important roles of neurotransmitter acetylcholine (ACh) and amyloid-β
(Aβ) in the pathogenesis of Alzheimer's disease (AD), the development of multi-target …