Chiral separation has already become a crucial topic for effectively utilizing superfluous
racemates synthesized by chemical means and satisfying the growing requirements for …

Crown ethers are macrocyclic hosts that can complex a wide range of inorganic and organic
cations as well as neutral guest species. Their widespread utilization in several areas of …

Chiral rotaxanes have attracted much attention in recent decades for their unique chirality
based on their interlocked structures. Thus, selective synthesis methods of chiral rotaxanes …

Chirality typically arises in molecules because of a rigidly chiral arrangement of covalently
bonded atoms. Less generally appreciated is that chirality can arise when molecules are …

Catenanes composed of two achiral rings that are oriented (Cnh symmetry) because of the
sequence of atoms they contain are referred to as topologically chiral. Here, we present the …

Active template auxiliary methodologies have previously been developed for the
stereoselective synthesis of chiral interlocked molecules in which the mechanical bond …

Achiral [2] catenanes composed of rings with inequivalent sides may adopt chiral co-
conformations. Their stereochemistry depends on the relative orientation of the interlocked …

Mechanical stereochemistry arises when the interlocking of stereochemically trivial covalent
subcomponents results in a stereochemically complex object. Although this general concept …

Conspectus Asymmetric organocatalysis has been considered to be an efficient and reliable
strategy for the stereoselective preparation of optically active chemicals. In particular, chiral …

In 1971, Schill recognized that a prochiral macrocycle encircling an oriented axle led to
geometric isomerism in rotaxanes. More recently, we identified an overlooked chiral …