Pronucleotides of 2′, 3′-Dideoxy-2′, 3′-Didehydrothymidine as Potent Anti-HIV Compounds
X Jia, D Schols, C Meier - Journal of Medicinal Chemistry, 2023 - ACS Publications
We report on the synthesis and evaluation of three different nucleotide prodrug systems:(i)
nucleoside triphosphate analogues in which the γ-phosph (on) ate has two different …
nucleoside triphosphate analogues in which the γ-phosph (on) ate has two different …
Lipophilic Nucleoside Triphosphate Prodrugs of Anti‐HIV Active Nucleoside Analogs as Potential Antiviral Compounds
X Jia, D Schols, C Meier - Advanced Science, 2023 - Wiley Online Library
Nucleoside analogs require three phosphorylation steps catalyzed by cellular kinases to
give their triphosphorylated metabolites. Herein, the synthesis of two types of triphosphate …
give their triphosphorylated metabolites. Herein, the synthesis of two types of triphosphate …
Antiviral Activity of Lipophilic Nucleoside Tetraphosphate Compounds
X Jia, D Schols, C Meier - Journal of Medicinal Chemistry, 2024 - ACS Publications
We report on the synthesis and characterization of three types of nucleoside tetraphosphate
derivatives 4–9 acting as potential prodrugs of d4T nucleotides:(i) the δ-phosph (on) ate is …
derivatives 4–9 acting as potential prodrugs of d4T nucleotides:(i) the δ-phosph (on) ate is …
Binding Affinity of Monoalkyl Phosphinic Acid Ligands toward Nanocrystal Surfaces
We recently introduced monoalkyl phosphinic acids as a ligand class for nanocrystal (NC)
synthesis. Their metal salts have interesting reactivity differences compared to metal …
synthesis. Their metal salts have interesting reactivity differences compared to metal …
Chromatographic performance of zidovudine imprinted polymers coated silica stationary phases
Z Song, Y Song, Y Wang, J Liu, Y Wang, W Lin… - Talanta, 2022 - Elsevier
Nowadays, molecularly imprinted polymers (MIPs) coated silica stationary phases (SPs)
have aroused great attention, owing to their good properties of high selectivity, good …
have aroused great attention, owing to their good properties of high selectivity, good …
Membrane-permeable tenofovir-di-and monophosphate analogues
X Jia, GA Kullik, M Bufano, A Brancale, D Schols… - European Journal of …, 2024 - Elsevier
The development of new antiviral agents such as nucleoside analogues or acyclic
nucleotide analogues (ANPs) and prodrugs thereof is an ongoing task. We report on the …
nucleotide analogues (ANPs) and prodrugs thereof is an ongoing task. We report on the …
Potent Anti‐HIV Activity of Alkyl‐Modified DiPPro‐Nucleotides
X Jia, D Schols, C Meier - Small Structures, 2024 - Wiley Online Library
Two convergent approaches for synthesizing a new class of nucleoside diphosphate
prodrugs bearing different nucleoside analogs are reported herein. The DiPPro‐nucleotides …
prodrugs bearing different nucleoside analogs are reported herein. The DiPPro‐nucleotides …
Triphosphate prodrugs of the anti-HIV-active compound 3′-deoxy-3′-fluorothymidine (FLT)
S Weising, S Weber, D Schols… - Journal of Medicinal …, 2022 - ACS Publications
3′-Fluoro-3′-deoxythymidine (FLT) was identified as one of the most potent inhibitors of
human immunodeficiency virus (HIV) replication. However, FLT also showed severe toxicity …
human immunodeficiency virus (HIV) replication. However, FLT also showed severe toxicity …
Monoalkyl phosphinic acids as ligands in nanocrystal synthesis
Ligands play a crucial role in the synthesis of colloidal nanocrystals. Nevertheless, only a
handful molecules are currently used, oleic acid being the most typical example. Here, we …
handful molecules are currently used, oleic acid being the most typical example. Here, we …
First- and Second-Generation Nucleoside Triphosphate Prodrugs: TriPPPro-Compounds for Antiviral Chemotherapy
X Jia, C Zhao, C Meier - Handbook of Chemical Biology of Nucleic Acids, 2023 - Springer
Currently, a number of biologically active nucleoside analogues are extensively used as
antiviral, anticancer, antiparasitic, and antibacterial therapeutic agents. However, when …
antiviral, anticancer, antiparasitic, and antibacterial therapeutic agents. However, when …