Pronucleotides of 2′, 3′-Dideoxy-2′, 3′-Didehydrothymidine as Potent Anti-HIV Compounds

X Jia, D Schols, C Meier - Journal of Medicinal Chemistry, 2023 - ACS Publications
We report on the synthesis and evaluation of three different nucleotide prodrug systems:(i)
nucleoside triphosphate analogues in which the γ-phosph (on) ate has two different …

Lipophilic Nucleoside Triphosphate Prodrugs of Anti‐HIV Active Nucleoside Analogs as Potential Antiviral Compounds

X Jia, D Schols, C Meier - Advanced Science, 2023 - Wiley Online Library
Nucleoside analogs require three phosphorylation steps catalyzed by cellular kinases to
give their triphosphorylated metabolites. Herein, the synthesis of two types of triphosphate …

Antiviral Activity of Lipophilic Nucleoside Tetraphosphate Compounds

X Jia, D Schols, C Meier - Journal of Medicinal Chemistry, 2024 - ACS Publications
We report on the synthesis and characterization of three types of nucleoside tetraphosphate
derivatives 4–9 acting as potential prodrugs of d4T nucleotides:(i) the δ-phosph (on) ate is …

Binding Affinity of Monoalkyl Phosphinic Acid Ligands toward Nanocrystal Surfaces

E Dhaene, S Coppenolle, L Deblock… - Chemistry of …, 2023 - ACS Publications
We recently introduced monoalkyl phosphinic acids as a ligand class for nanocrystal (NC)
synthesis. Their metal salts have interesting reactivity differences compared to metal …

Chromatographic performance of zidovudine imprinted polymers coated silica stationary phases

Z Song, Y Song, Y Wang, J Liu, Y Wang, W Lin… - Talanta, 2022 - Elsevier
Nowadays, molecularly imprinted polymers (MIPs) coated silica stationary phases (SPs)
have aroused great attention, owing to their good properties of high selectivity, good …

Membrane-permeable tenofovir-di-and monophosphate analogues

X Jia, GA Kullik, M Bufano, A Brancale, D Schols… - European Journal of …, 2024 - Elsevier
The development of new antiviral agents such as nucleoside analogues or acyclic
nucleotide analogues (ANPs) and prodrugs thereof is an ongoing task. We report on the …

Potent Anti‐HIV Activity of Alkyl‐Modified DiPPro‐Nucleotides

X Jia, D Schols, C Meier - Small Structures, 2024 - Wiley Online Library
Two convergent approaches for synthesizing a new class of nucleoside diphosphate
prodrugs bearing different nucleoside analogs are reported herein. The DiPPro‐nucleotides …

Triphosphate prodrugs of the anti-HIV-active compound 3′-deoxy-3′-fluorothymidine (FLT)

S Weising, S Weber, D Schols… - Journal of Medicinal …, 2022 - ACS Publications
3′-Fluoro-3′-deoxythymidine (FLT) was identified as one of the most potent inhibitors of
human immunodeficiency virus (HIV) replication. However, FLT also showed severe toxicity …

Monoalkyl phosphinic acids as ligands in nanocrystal synthesis

E Dhaene, R Pokratath, O Aalling-Frederiksen… - ACS …, 2022 - ACS Publications
Ligands play a crucial role in the synthesis of colloidal nanocrystals. Nevertheless, only a
handful molecules are currently used, oleic acid being the most typical example. Here, we …

First- and Second-Generation Nucleoside Triphosphate Prodrugs: TriPPPro-Compounds for Antiviral Chemotherapy

X Jia, C Zhao, C Meier - Handbook of Chemical Biology of Nucleic Acids, 2023 - Springer
Currently, a number of biologically active nucleoside analogues are extensively used as
antiviral, anticancer, antiparasitic, and antibacterial therapeutic agents. However, when …