Amiodarone is a potent antidysrhythmic agent that can cause potentially life-threatening
pulmonary fibrosis. Accumulating evidence has demonstrated that myofibroblast …

Amiodarone (AM) is one of the most effective antiarrhythmic drugs and normally
administrated by intravenous infusion which is liable to cause serious phlebitis. The …

Background: Considering the high toxicity and limited therapies available for treating
visceral leishmaniasis (VL), the drug repositioning approach represents a faster way to …

Abstract Treatment with cationic amphiphilic drugs like Amiodarone leads to development of
phospholipidosis, a type of lysosomal storage disorder characterized by excessive …

We present a case report of an 80-year-old woman with volume overload thought initially to
be secondary to heart failure, but determined to be amiodarone-induced acute and chronic …

目的分析我院胺碘酮所致不良反应(ADR) 的发生特点及相关因素, 为临床安全,
合理用药提供参考. 方法收集我院2008 年1 月~ 2014 年6 月住院及门诊患者中胺碘酮ADR …

Mitochondrial complex I, a large respiratory enzyme located in the inner mitochondrial
membrane, catalyses electron transfer from NADH to ubiquinone while concomitantly …

We report here a novel in vitro experimental system, the metabolism-dependent cytotoxicity
assay (MDCA), for the definition of the roles of hepatic drug metabolism in toxicity. MDCA …

The antiarrhythmic effect of amiodarone and its analogue dronedarone is caused by their
direct actions on several cardiomyocyte sarcolemmal ion currents. However, whether their …

L'amiodarone è un farmaco antiaritmico di classe III utilizzato nella gestione di aritmie
ventricolari e sopraventricolari. Sebbene sia nota la tossicità da impiego prolungato di …