BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

For decades, the mechanisms responsible for germ cell depletion from the ovary, either
directly during the perinatal period or indirectly via follicular atresia during postnatal life …

Female sterility resulting from oocyte destruction is an unfortunate, and in many cases
inevitable, consequence of chemotherapy. We show that unfertilized mouse oocytes …

We have recently demonstrated the existence of a neuromodulatory regulation of prolactin
secretion by the opioid system showing a paradoxical opioid-induced prolactin suppression …

Current studies have shown that atresia of ovarian follicles is induced through apoptosis in
granulosa cells. Several articles have been devoted to study of the molecular mechanisms …

abstract The Wilms' tumor 1 (wt1) gene is one of at least three genes that are involved in the
development of Wilms' tumor, a pediatric kidney cancer. The expression pattern of the gene …

Abstract Estradiol-17β (E2) affects late follicular development, whereas primordial follicle
differentiation and early activation are believed to be independent of E2. To test this …

Novel Insights into the Molecular Mechanisms of Human Thyrotropin Action: Structural,
Physiological, and Therapeutic Implications for the Glycoprotein Hormone Family | Endocrine …

Failure to ovulate is a major cause of infertility. The critical pathway that induces ovulation
involves the EGF and MAPK phosphorylation, but studies in rodents have suggested that the …

In the present study we have examined the presence of Fas, Fas ligand (FasL), and p53 in
rat granulosa cells during follicular development and atresia, especially in relation to the …