Formaldehyde (FA) is a xenobiotic air pollutant and its universal distribution causes a
widespread exposure to humans. This review aimed to bring updated information …

Covalent binding between proteins and a DNA strand produces DNA-protein crosslinks
(DPC). DPC are one of the most deleterious types of DNA damage, leading to the blockage …

Exposure to the physicochemical agents that interact with nucleic acids (NA) may lead to
modification of DNA and RNA (ie, NA modifications), which have been associated with …

Covalent binding of proteins to DNA forms DNA-protein crosslinks (DPCs), which represent
cytotoxic DNA lesions that interfere with essential processes such as DNA replication and …

Genome integrity is essential for life and, as a result, DNA repair systems evolved to remove
unavoidable DNA lesions from cellular DNA. Many forms of life possess the capacity to …

Comprehensive Summary Formaldehyde (FA) plays critical roles in Alzheimer's disease and
the associations between FA and Alzheimer's disease (AD) are still obscure. To reveal FA …

Cancer remains the second most frequent cause of death in human populations worldwide,
which has been reflected in the emphasis placed on management of risk from environmental …

As a widespread industrial chemical, formaldehyde carcinogenicity has been highly
controversial. Meanwhile, formaldehyde is an essential metabolite in all living cells …

Fanconi anemia (FA), a genetic DNA repair disorder characterized by marrow failure and
cancer susceptibility. In FA mice, metformin improves blood counts and delays tumor …

Accumulating evidence suggests that DNA lesion-induced DNA–protein cross-links (DPCs)
interrupt normal DNA metabolic processes, such as transcription, replication, and repair …