In the eukaryotic cell, capping of mRNA 5′ ends is an essential structural modification that
allows efficient mRNA translation, directs pre-mRNA splicing and mRNA export from the …

Highlights•Approval of first endonuclease inhibitor for influenza treatment.•Represents a
new class of influenza drug.•Single dose is clinically effective.For the first time in nearly 20 …

Baloxavir acid (BXA), derived from the prodrug baloxavir marboxil (BXM), potently and
selectively inhibits the cap-dependent endonuclease within the polymerase PA subunit of …

Influenza virus is a segmented, negative strand RNA virus with each genome segment being
packaged in a distinct ribonucleoprotein particle (RNP). The RNP consists of the …

Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …

Bunyaviruses are a large family of segmented RNA viruses which, like influenza virus, use a
cap-snatching mechanism for transcription whereby short capped primers derived by …

It is generally recognised that novel antiviral drugs, less prone to resistance, would be a
desirable alternative to current drug options in order to be able to treat potentially serious …

Metal-binding proteins (MBPs) have various and important biological roles in all living
species and many human diseases are intricately linked to dysfunctional MBPs. Here, we …

Emerging influenza viruses are a serious threat to human health because of their pandemic
potential. A promising target for the development of novel anti-influenza therapeutics is the …

Influenza polymerase (FluPol) plays a key role in the viral infection cycle by transcribing and
replicating the viral genome. FluPol is a multifunctional, heterotrimeric enzyme with cap …