Visualization of metabolites and microbes at high spatial resolution using MALDI mass spectrometry imaging and in situ fluorescence labeling

P Bourceau, B Geier, V Suerdieck, T Bien… - Nature …, 2023 - nature.com
Label-free molecular imaging techniques such as matrix-assisted laser desorption ionization
mass spectrometry imaging (MALDI-MSI) enable the direct and simultaneous mapping of …

Multimodal imaging based on vibrational spectroscopies and mass spectrometry imaging applied to biological tissue: a multiscale and multiomics review

M Tuck, L Blanc, R Touti, NH Patterson… - Analytical …, 2020 - ACS Publications
Molecular imaging has the potential to unearth important spatial and temporal relationships
in biological systems, including intercellular signaling as well as environmentally-cued …

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

AK Najumudeen, F Ceteci, SK Fey, G Hamm… - Nature …, 2021 - nature.com
Oncogenic KRAS mutations and inactivation of the APC tumor suppressor co-occur in
colorectal cancer (CRC). Despite efforts to target mutant KRAS directly, most therapeutic …

Peak learning of mass spectrometry imaging data using artificial neural networks

WM Abdelmoula, BGC Lopez, EC Randall… - Nature …, 2021 - nature.com
Mass spectrometry imaging (MSI) is an emerging technology that holds potential for
improving, biomarker discovery, metabolomics research, pharmaceutical applications and …

MSiReader v1. 0: evolving open-source mass spectrometry imaging software for targeted and untargeted analyses

MT Bokhart, M Nazari, KP Garrard… - Journal of The …, 2017 - ACS Publications
A major update to the mass spectrometry imaging (MSI) software MSiReader is presented,
offering a multitude of newly added features critical to MSI analyses. MSiReader is a free …

Spatial metabolomics of in situ host–microbe interactions at the micrometre scale

B Geier, EM Sogin, D Michellod, M Janda… - Nature …, 2020 - nature.com
Spatial metabolomics describes the location and chemistry of small molecules involved in
metabolic phenotypes, defence molecules and chemical interactions in natural communities …

MSiReader: an open-source interface to view and analyze high resolving power MS imaging files on Matlab platform

G Robichaud, KP Garrard, JA Barry… - Journal of the …, 2013 - ACS Publications
During the past decade, the field of mass spectrometry imaging (MSI) has greatly evolved, to
a point where it has now been fully integrated by most vendors as an optional or dedicated …

Combined Analysis of the Fruit Metabolome and Transcriptome Reveals Candidate Genes Involved in Flavonoid Biosynthesis in Actinidia arguta

Y Li, J Fang, X Qi, M Lin, Y Zhong, L Sun… - International journal of …, 2018 - mdpi.com
To assess the interrelation between the change of metabolites and the change of fruit color,
we performed a combined metabolome and transcriptome analysis of the flesh in two …

Ultra-high mass resolving power, mass accuracy, and dynamic range MALDI mass spectrometry imaging by 21-T FT-ICR MS

AP Bowman, GT Blakney, CL Hendrickson… - Analytical …, 2020 - ACS Publications
Detailed characterization of complex biological surfaces by matrix-assisted laser
desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrumentation …

Chemical intervention in plant sugar signalling increases yield and resilience

CA Griffiths, R Sagar, Y Geng, LF Primavesi, MK Patel… - Nature, 2016 - nature.com
The pressing global issue of food insecurity due to population growth, diminishing land and
variable climate can only be addressed in agriculture by improving both maximum crop yield …