Pharmacokinetics, metabolism, distribution and permeability of nanomedicine
S Ravindran, JK Suthar, R Rokade… - Current drug …, 2018 - ingentaconnect.com
Background: Medical application of nanotechnology is termed as Nanomedicine and is
widely used in healthcare industries. Nanotechnology has helped Physicians, Scientists and …
widely used in healthcare industries. Nanotechnology has helped Physicians, Scientists and …
Modeling reactivity to biological macromolecules with a deep multitask network
Most small-molecule drug candidates fail before entering the market, frequently because of
unexpected toxicity. Often, toxicity is detected only late in drug development, because many …
unexpected toxicity. Often, toxicity is detected only late in drug development, because many …
Nanomedicine: Bioavailability, biotransformation and biokinetics
S Ravindran, AJ Tambe, JK Suthar… - Current drug …, 2019 - ingentaconnect.com
Background: Nanomedicine is increasingly used to treat various ailments. Biocompatibility of
nanomedicine is primarily governed by its properties such as bioavailability …
nanomedicine is primarily governed by its properties such as bioavailability …
Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism
Gefitinib (GEF), an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is
widely used for the treatment of cancers, particularly non-small cell lung cancer. However, its …
widely used for the treatment of cancers, particularly non-small cell lung cancer. However, its …
[图书][B] Cytochrome P450 2D6: structure, function, regulation and polymorphism
S Zhou - 2018 - taylorfrancis.com
Cytochromes are proteins that catalyze electron transfer reactions of well-known metabolic
pathways and are classified in various superfamilies. The CYP, or P450, superfamily …
pathways and are classified in various superfamilies. The CYP, or P450, superfamily …
Modeling the bioactivation and subsequent reactivity of drugs
Electrophilically reactive drug metabolites are implicated in many adverse drug reactions. In
this mechanism—termed bioactivation—metabolic enzymes convert drugs into reactive …
this mechanism—termed bioactivation—metabolic enzymes convert drugs into reactive …
[HTML][HTML] Pharmacokinetics of intravenous pan-class I phosphatidylinositol 3-kinase (PI3K) inhibitor [14C]copanlisib (BAY 80-6946) in a mass balance study in healthy …
M Gerisch, T Schwarz, D Lang, G Rohde, S Reif… - Cancer Chemotherapy …, 2017 - Springer
Purpose To determine the pharmacokinetics of radiolabeled copanlisib (BAY 80-6946) in
healthy male volunteers and to investigate the disposition and biotransformation of …
healthy male volunteers and to investigate the disposition and biotransformation of …
Microbioreactors and perfusion bioreactors for microbial and mammalian cell culture
S Ravindran, P Singh, S Nene, V Rale… - Biotechnology and …, 2019 - books.google.com
Screening for novel producer strains and enhanced therapeutic production at reduced cost
has been the focus of most of the biopharmaceutical industries. The obligation to carry out …
has been the focus of most of the biopharmaceutical industries. The obligation to carry out …
Technologies and strategies to characterize and quantitate metabolites in drug discovery and development
S Ravindran, A Jadhav, P Surve… - Biomedical …, 2014 - Wiley Online Library
Pharmacokinetics and toxicokinetics studies rely on the quantitation of drugs and its
metabolites. Drug metabolism studies are based on the characterization of the structure of …
metabolites. Drug metabolism studies are based on the characterization of the structure of …
In vitro biotransformation in drug discovery
In vitro Biotransformation studies play a crucial role in drug discovery program that
determine the fate of the new chemical entities (NCE's). Enzyme rich matrices such as …
determine the fate of the new chemical entities (NCE's). Enzyme rich matrices such as …