Significance of miRNAs on the thyroid cancer progression and resistance to treatment with special attention to the role of cross-talk between signaling pathways

AS Doghish, HA El-Mahdy, A Ismail, M Hegazy… - … -Research and Practice, 2023 - Elsevier
Thyroid cancer (TC) is the most prevalent endocrine malignant tumor. It has many types, the
Papillary thyroid cancer (PTC)(most common and follicular thyroid carcinoma (FTC). Several …

miRNAs as Cornerstones in Chronic Lymphocytic Leukemia Pathogenesis and Therapeutic Resistance–An emphasis on the interaction of signaling pathways

AS Doghish, AI Abulsoud, SS Elshaer… - … -Research and Practice, 2023 - Elsevier
Chronic lymphocytic leukemia (CLL) accounts for the vast majority of cases of leukemia.
Patients of advanced age are more likely to develop the condition, which has a highly varied …

The potential role of miRNAs in the pathogenesis of salivary gland cancer–A Focus on signaling pathways interplay

AI Abulsoud, SS Elshaer, AA El-Husseiny… - … -Research and Practice, 2023 - Elsevier
Salivary gland cancer (SGC) is immensely heterogeneous, both in terms of its physical
manifestation and its aggressiveness. Developing a novel diagnostic and prognostic …

STAT3 inhibitors: a novel insight for anticancer therapy of pancreatic cancer

X Li, W Jiang, S Dong, W Li, W Zhu, W Zhou - Biomolecules, 2022 - mdpi.com
The signal transducer and activator of transcription (STAT) is a family of intracellular
cytoplasmic transcription factors involved in many biological functions in mammalian signal …

The Role of miRNAs in the Development, Proliferation, and Progression of Endometrial Cancer

A Bogaczyk, I Zawlik, T Zuzak, M Kluz… - International Journal of …, 2023 - mdpi.com
Endometrial cancer is one of the most common cancers in developing and developed
countries. Although the detection of this cancer is high at the early stages, there is still a lack …

Pathological role of inflammation in ocular disease progress and its targeting by mesenchymal stem cells (MSCs) and their exosome; current status and prospect

A Nouralishahi, N Fazlinejad, RDC Pecho… - … -Research and Practice, 2023 - Elsevier
Because of their unique capacity for differentiation to a diversity of cell lineages and
immunosuppressive properties, mesenchymal stem cells (MSC) are being looked at as a …

Hijacking 5-Fluorouracil Chemoresistance in Triple Negative Breast Cancer via microRNAs-Loaded Chitosan Nanoparticles

SA Fahmy, NK Mahdy, AH Mohamed… - International Journal of …, 2024 - mdpi.com
Chemotherapy is still the mainstay of treatment for triple-negative breast cancer (TNBC)
patients. Yet only 20% of TNBC patients show a pathologic complete response (pCR) after …

The Role of microRNAs in Gene Expression and Signaling Response of Tumor Cells to an Acidic Environment

A Riemann, M Rauschner, S Reime… - International Journal of …, 2023 - mdpi.com
Many tumors are characterized by marked extracellular acidosis due to increased glycolytic
metabolism, which affects gene expression and thereby tumor biological behavior. At the …

The role of the JAK/STAT3 signaling pathway in acquired corneal diseases

D Song, Q Yang, X Li, K Chen, J Tong… - Experimental Eye …, 2023 - Elsevier
Acquired corneal diseases such as dry eye disease (DED), keratitis and corneal alkali burns
are significant contributors to vision impairment worldwide, and more effective and …

Stem Cell‐Associated Signatures Help to Predict Diagnosis and Prognosis in Ovarian Serous Cystadenocarcinoma

L Li, W Zhang, J Qiu, W Zhang, M Lu… - Stem Cells …, 2023 - Wiley Online Library
Ovarian serous cystadenocarcinoma (OV) is a fatal gynecologic cancer with a five‐year
survival rate of only 46%. Resistance to platinum‐based chemotherapy is a prevalent factor …