Mitochondria are central hubs of cellular metabolism that also play key roles in signaling
and disease. It is therefore fundamentally important that mitochondrial quality and activity …

Lipid–protein interactions in cells are involved in various biological processes, including
metabolism, trafficking, signaling, host–pathogen interactions, and transmembrane …

An elevated bone microenvironmental reactive oxygen species (ROS) level is a hallmark of
osteoporosis that often leads to the dysfunction of bone-related mesenchymal stem cells …

Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of
Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases …

Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized
mitochondria to maintain mitochondrial activity and cellular homeostasis. Several pathways …

The complex relationship between mitochondrial dynamics and autophagy illustrates how
two cellular housekeeping processes are intimately linked, illuminating fundamental …

The mechanochemical GTPase dynamin-related protein 1 (Drp1) catalyzes mitochondrial
and peroxisomal fission, but the regulatory mechanisms remain ambiguous. Here we find …

Mitochondria, which generate ATP through aerobic respiration, also have important
noncanonical functions. Mitochondria are dynamic organelles, that engage in fission …

The dynamic nature of mitochondria, which can fuse, divide and move throughout the cell,
allows these critical organelles to adapt their function in response to cellular demands, and …

Fission protein 1 (FIS1) and dynamin-related protein 1 (DRP1) were initially described as
being evolutionarily conserved for mitochondrial fission, yet in humans the role of FIS1 in …