Introduction Oral delivery is the most common administrated drug delivery path. However,
oral administration of lipophilic drugs has some limitations: they have poor dose-response …

Drug metabolism is a major determinant of drug concentrations in the body. Drug-drug
interactions (DDIs) caused by the co-administration of multiple drugs can lead to alteration in …

Beauvericin (BEA) is a well-known mycotoxin produced by many fungi, including Beaveria
bassiana. The purpose of this study was to evaluate the in vitro distribution and metabolism …

Recently, the well-known geographically wide distribution of sporotrichosis in Brazil,
combined with the difficulties of effective domestic feline treatment, has emphasized the …

Background Gliclazide, a second-generation sulfonylurea derivative still widely used as a
second-line treatment for type 2 diabetes mellitus, is well known to be subject to …

Since its inception, selective serotonin reuptake inhibitors (SSRIs), such as sertraline (SRT),
have been an important drug that affects mood and regulates serotonin levels in the …

Gastric cancer is considered a class 1 carcinogen that is closely linked to infection with
Helicobacter pylori (H. pylori), which affects over 1 million people each year. However, the …

Time-dependent inhibition of cytochrome P450 (CYP) enzymes has been observed for a few
glucuronide metabolites of clinically used drugs. Here, we investigated the inhibitory …

We describe the development and validation of a novel liquid chromatography assay
(HPLC/PDA) for simultaneous quantification of voriconazole, itraconazole, and …

The tyrosine kinase inhibitor sorafenib (SOR) is being used increasingly in combination with
other anticancer agents like paclitaxel, but this increases the potential for drug toxicity. SOR …