The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …

Extracellular vesicles (EVs) are released by most cell types but providing evidence for their
physiological relevance remains challenging due to a lack of appropriate model organisms …

Multicellular aggregates of circulating tumor cells (CTC clusters) are potent initiators of
distant organ metastasis. However, it is currently assumed that CTC clusters are too large to …

Wound angiogenesis is an integral part of tissue repair and is impaired in many pathologies
of healing. Here, we investigate the cellular interactions between innate immune cells and …

Background Moyamoya disease is an idiopathic vascular disorder of intracranial arteries. Its
susceptibility locus has been mapped to 17q25. 3 in Japanese families, but the susceptibility …

Up to 99% of systemically administered nanoparticles are cleared through the liver. Within
the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells) …

The focus of this review is to provide an overview of the current state of knowledge of
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …

In this study we describe a model system that allows continuous in vivo observation of the
vertebrate embryonic vasculature. We find that the zebrafish fli1 promoter is able to drive …

Human pathologies such as vascular malformations, hemorrhagic stroke, and edema have
been associated with defects in the organization of endothelial cell junctions. Understanding …