Interactions with aromatic rings in chemical and biological recognition

EA Meyer, RK Castellano… - Angewandte Chemie …, 2003 - Wiley Online Library
Intermolecular interactions involving aromatic rings are key processes in both chemical and
biological recognition. Their understanding is essential for rational drug design and lead …

Fluorinated phosphonates: Synthesis and biomedical application

VD Romanenko, VP Kukhar - Chemical reviews, 2006 - ACS Publications
The phosphate moiety (PO4-2) is the common structural motif of a wide range of natural
phosphorus-based biologically active compounds, which play important roles as metabolic …

Wechselwirkungen mit aromatischen Ringen in chemischen und biologischen Erkennungsprozessen

EA Meyer, RK Castellano, F Diederich - Angewandte Chemie, 2003 - Wiley Online Library
Abstract Zwischenmolekulare Wechselwirkungen unter Beteiligung aromatischer Ringe sind
Schlüsselvorgänge sowohl in chemischen als auch in biologischen Erkennungsprozessen …

Allosteric modulation of the adenosine A2A receptor by cholesterol

SK Huang, O Almurad, RJ Pejana, ZA Morrison… - Elife, 2022 - elifesciences.org
Cholesterol is a major component of the cell membrane and commonly regulates membrane
protein function. Here, we investigate how cholesterol modulates the conformational …

Methods for the preparation of diasteromerically pure phosphoramidate prodrugs

A Cho, MONH Clarke, SA Wolckenhauer - US Patent 9,090,642, 2015 - Google Patents
US9090642B2 - Methods for the preparation of diasteromerically pure phosphoramidate
prodrugs - Google Patents US9090642B2 - Methods for the preparation of diasteromerically pure …

A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates

V Denavit, D Lainé, J St-Gelais, PA Johnson… - Nature …, 2018 - nature.com
The replacement of hydroxyl groups by fluorine atoms on hexopyranose scaffolds may allow
access to the discovery of new chemical entities possessing unique physical, chemical and …

Stereoselective Synthesis of Fluorinated Galactopyranosides as Potential Molecular Probes for Galactophilic Proteins: Assessment of Monofluorogalactoside–LecA …

V Denavit, D Lainé, C Bouzriba… - … A European Journal, 2019 - Wiley Online Library
The replacement of hydroxyl groups by fluorine atoms on hexopyranoside scaffolds may
allow access to invaluable tools for studying various biochemical processes. As part of …

1′-substituted carba-nucleoside analogs for antiviral treatment

T Butler, A Cho, CU Kim, JP Parrish… - US Patent …, 2014 - Google Patents
4,816,570 A 3/1989 Farquhar 4,968,788 A 1 1/1990 Farquhar 5,663,159 A 9/1997 Starrett,
Jr. et al. 5,792,756 A 8/1998 Starrett, Jr. et al. 6,312,662 B1 1 1/2001 Erion et al. 6,476,030 …

Hit-to-lead optimization of novel phenyl imidazole carboxamides that are active against Leishmania donovani

N McNamara, E Saunders, S Varghese… - European Journal of …, 2022 - Elsevier
Visceral leishmaniasis is a potentially fatal disease caused by the parasitic protists,
Leishmania donovani and L. infantum. Current treatments remain unsuitable due to cost, the …

Processes and intermediates for the preparation of 1′-substituted carba-nucleoside analogs

T Butler, A Cho, BR Graetz, CU Kim… - US Patent …, 2018 - Google Patents
US10023600B2 - Processes and intermediates for the preparation of 1′-substituted carba-nucleoside
analogs - Google Patents US10023600B2 - Processes and intermediates for the preparation …