A link between oxidative stress and hypertension has been firmly established in multiple
animal models of hypertension but remains elusive in humans. While initial studies focused …

This review describes and summarizes the role of neuronal nitric oxide synthase (nNOS) on
the central nervous system, particularly on brain regions such as the ventrolateral medulla …

Rationale: Endothelial dysfunction is an important determinant risk factor for the
development of hypertension and its complications. Thus, identification of potential …

The family of nitric oxide synthases (NOS) has significant importance in various
physiological mechanisms and is also involved in many pathological processes. Three NOS …

Abstract Significance: NADPH oxidases (Noxs), of which there are seven isoforms (Nox1–5,
Duox1/Duox2), are professional oxidases functioning as reactive oxygen species (ROS) …

Endothelial dysfunction represents a major cardiovascular risk factor for hypertension. Sp1
and Sp3 belong to the specificity protein and Krüppel-like transcription factor families. They …

Nitric oxide (NO) is an imperative regulator of the cardiovascular system and is a critical
mechanism in preventing the pathogenesis and progression of the diseased heart. The …

The essential role of the endothelium in vascular homeostasis is associated with the release
of endothelium-dependent relaxing and contractile factors (EDRF and EDCF, respectively) …

The perivascular adipose tissue (PVAT) is located around the adventitia, composed
primarily by adipocytes, stromal cells, leukocytes, fibroblasts and capillaries. It is well …

Abstract Aims Nitric oxide synthases (NOSs) are key enzymes regulating vascular function.
Previously, we reported that β-adrenergic (β-AR) overstimulation, a common feature of …