The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround
the soma and proximal dendrites of certain neurons in the central nervous system …

It is well known that only a small proportion of the human genome code for proteins; the rest
belong to the family of RNAs that do not code for protein and are known as non-coding …

Growing evidence points to a critical involvement of the extracellular matrix (ECM) in the
pathophysiology of schizophrenia (SZ). Decreases of perineuronal nets (PNNs) and altered …

Decades of research have produced extensive evidence of the contribution of genetic
factors to the efficacy and toxicity of antipsychotics. Numerous genetic variants in genes …

Reelin is an extracellular matrix glycoprotein reduced in brain regions (the prefrontal cortex
and the hippocampus) of patients with schizophrenia. There are diverse rodent models of …

Genome-wide premortem DNA methylation patterns can be computationally reconstructed
from high-coverage DNA sequences of ancient samples. Because DNA methylation is more …

Green space exposure has been associated with improved mental, physical and general
health. However, the underlying biological mechanisms remain largely unknown. The aim of …

DNA methylation (DNAm) is one of the most frequently studied epigenetic mechanisms
facilitating the interplay of genomic and environmental factors, which can contribute to …

Chaigui granules were a traditional Chinese medicine (TCM) preparation with
antidepressant effects derived from a famous antidepressant prescription. It was of great …