Apelin is an endogenous peptide acting on the APJ receptor. It consists of several isoforms
characterized by different numbers of amino acids. The number of amino acids in the active …

Apelin, the endogenous ligand of APJ which is a member of G protein-coupled receptors,
has been shown to be expressed in a variety of tissues in vivo and to exert significant …

Endoplasmic reticulum (ER) stress is activated during and contributes to ischemia-
reperfusion (I/R) injury. Attenuation of ER stress-induced apoptosis protects the heart …

BACKGROUND: Although the mechanisms and pathways mediating ARDS have been
studied extensively, less attention has been given to the mechanisms and pathways that …

We studied whether apelin-13 is cardioprotective against ischemia/reperfusion injury if given
as either a pre-or postconditioning mimetic and whether the improved postischemic …

Apelin-13 in blood pressure regulation and cardiovascular di... : Current Opinion in Nephrology
and Hypertension Apelin-13 in blood pressure regulation and cardiovascular disease : Current …

Stroke is one of the leading causes of death and disability worldwide, and ischemic stroke
accounts for approximately 87% of cases. Improving post-stroke recovery is a major …

It is known that apelin has definite protective effects on various cardiovascular diseases;
however, the mechanism through which hypertension with heart failure (H-HF) is affected by …

Acute cardiac dysfunction caused by stroke-heart syndrome (SHS) is the second leading
cause of stroke-related death. The inflammatory response plays a significant role in the …

Aim Apelin, the ligand of the G‐protein‐coupled receptor (GPCR) APJ, exerts a post‐
conditioning‐like protection against ischaemia/reperfusion injury through activation of PI3K …