Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

Mitochondria are key organelles for cellular energetics, metabolism, signaling, and quality
control and have been linked to various diseases. Different views exist on the composition of …

INTRODUCTION The emergence of three lethal coronaviruses in< 20 years and the urgency
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies …

Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …

Obesity increases the risk of mortality because of metabolic sequelae such as type 2
diabetes and cardiovascular disease. Thermogenesis by adipocytes can counteract obesity …

Mitochondrial biogenesis and functions depend on the import of precursor proteins via the
'translocase of the outer membrane'(TOM complex). Defects in protein import lead to an …

Mutations in GBA1, the gene encoding the lysosomal enzyme β-glucocerebrosidase
(GCase), which cause Gaucher's disease, are the most frequent genetic risk factor for …

INTRODUCTION Mitochondria are dynamic organelles that coordinate many cellular
functions that are essential for life, including diverse metabolic processes, cell division and …

Mitochondria are central to energy production, metabolism and signaling, and apoptosis. To
make new mitochondria from preexisting mitochondria, the cell needs to import …