Establishing the contribution of active histone methylation marks to the aging transcriptional landscape of Drosophila photoreceptors

J Jauregui-Lozano, SE McGovern, KM Bakhle… - Scientific Reports, 2023 - nature.com
Studies in multiple organisms have shown that aging is accompanied by several molecular
phenotypes that include dysregulation of chromatin. Since chromatin regulates DNA-based …

Genetic screening reveals cone cell-specific factors as common genetic targets modulating rival-induced prolonged mating in male Drosophila melanogaster

Y Sun, X Zhang, Z Wu, W Li… - G3: Genes, Genomes …, 2025 - academic.oup.com
Male–male social interactions exert a substantial impact on the transcriptional regulation of
genes associated with aggression and mating behavior in male Drosophila melanogaster …

Aging and light stress result in overlapping and unique gene expression changes in photoreceptors

SE Escobedo, SC Stanhope, Z Dong, VM Weake - Genes, 2022 - mdpi.com
Advanced age is one of the leading risk factors for vision loss and eye disease.
Photoreceptors are the primary sensory neurons of the eye. The extended photoreceptor cell …

An Adapted GeneSwitch Toolkit for Comparable Cellular and Animal Models: A Proof of Concept in Modeling Charcot-Marie-Tooth Neuropathy

L Morant, ML Petrovic-Erfurth, A Jordanova - International journal of …, 2023 - mdpi.com
Investigating the impact of disease-causing mutations, their affected pathways, and/or
potential therapeutic strategies using disease modeling often requires the generation of …

Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration

Y Sakakibara, R Yamashiro, S Chikamatsu, Y Hirota… - Iscience, 2023 - cell.com
Drosophila Toll-9 is most closely related to mammalian Toll-like receptors; however,
physiological functions of Toll-9 remain elusive. We examined the roles of Toll-9 in fly brains …

A TRiP RNAi screen to identify molecules necessary for Drosophila photoreceptor differentiation

J Rylee, S Mahato, J Aldrich, E Bergh, B Sizemore… - G3, 2022 - academic.oup.com
Drosophila rhabdomeric terminal photoreceptor differentiation is an extended process taking
several days to complete. Following ommatidial patterning by the morphogenetic furrow …

Genome-Wide Association Study and transcriptome analysis reveals a complex gene network that regulates opsin gene expression and cell fate determination in …

JC Aldrich, LA Vanderlinden, TL Jacobsen, C Wood… - …, 2024 - pmc.ncbi.nlm.nih.gov
Background: An animal's ability to discriminate between differing wavelengths of light (ie,
color vision) is mediated, in part, by a subset of photoreceptor cells that express opsins with …

Developmental timing of Drosophila pachea pupae is robust to temperature changes

BM Lefèvre, S Mienanzambi, M Lang - Journal of Thermal Biology, 2022 - Elsevier
Rearing temperature is correlated with the timing and speed of development in a wide range
of poikiloterm animals that do not regulate their body temperature. However, exceptions …

Analysis of genetic and protein interactions associated with mutant Huntingtin-induced degeneration

R Spicer - 2024 - orca.cardiff.ac.uk
FoxP1 and Mef2C are two genes important for mouse striatal development, the brain region
that is most vulnerable the effects of the mutated protein responsible for Huntington's …