Establishing the contribution of active histone methylation marks to the aging transcriptional landscape of Drosophila photoreceptors
Studies in multiple organisms have shown that aging is accompanied by several molecular
phenotypes that include dysregulation of chromatin. Since chromatin regulates DNA-based …
phenotypes that include dysregulation of chromatin. Since chromatin regulates DNA-based …
Genetic screening reveals cone cell-specific factors as common genetic targets modulating rival-induced prolonged mating in male Drosophila melanogaster
Y Sun, X Zhang, Z Wu, W Li… - G3: Genes, Genomes …, 2025 - academic.oup.com
Male–male social interactions exert a substantial impact on the transcriptional regulation of
genes associated with aggression and mating behavior in male Drosophila melanogaster …
genes associated with aggression and mating behavior in male Drosophila melanogaster …
Aging and light stress result in overlapping and unique gene expression changes in photoreceptors
SE Escobedo, SC Stanhope, Z Dong, VM Weake - Genes, 2022 - mdpi.com
Advanced age is one of the leading risk factors for vision loss and eye disease.
Photoreceptors are the primary sensory neurons of the eye. The extended photoreceptor cell …
Photoreceptors are the primary sensory neurons of the eye. The extended photoreceptor cell …
An Adapted GeneSwitch Toolkit for Comparable Cellular and Animal Models: A Proof of Concept in Modeling Charcot-Marie-Tooth Neuropathy
L Morant, ML Petrovic-Erfurth, A Jordanova - International journal of …, 2023 - mdpi.com
Investigating the impact of disease-causing mutations, their affected pathways, and/or
potential therapeutic strategies using disease modeling often requires the generation of …
potential therapeutic strategies using disease modeling often requires the generation of …
Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration
Y Sakakibara, R Yamashiro, S Chikamatsu, Y Hirota… - Iscience, 2023 - cell.com
Drosophila Toll-9 is most closely related to mammalian Toll-like receptors; however,
physiological functions of Toll-9 remain elusive. We examined the roles of Toll-9 in fly brains …
physiological functions of Toll-9 remain elusive. We examined the roles of Toll-9 in fly brains …
A TRiP RNAi screen to identify molecules necessary for Drosophila photoreceptor differentiation
J Rylee, S Mahato, J Aldrich, E Bergh, B Sizemore… - G3, 2022 - academic.oup.com
Drosophila rhabdomeric terminal photoreceptor differentiation is an extended process taking
several days to complete. Following ommatidial patterning by the morphogenetic furrow …
several days to complete. Following ommatidial patterning by the morphogenetic furrow …
Genome-Wide Association Study and transcriptome analysis reveals a complex gene network that regulates opsin gene expression and cell fate determination in …
JC Aldrich, LA Vanderlinden, TL Jacobsen, C Wood… - …, 2024 - pmc.ncbi.nlm.nih.gov
Background: An animal's ability to discriminate between differing wavelengths of light (ie,
color vision) is mediated, in part, by a subset of photoreceptor cells that express opsins with …
color vision) is mediated, in part, by a subset of photoreceptor cells that express opsins with …
Developmental timing of Drosophila pachea pupae is robust to temperature changes
BM Lefèvre, S Mienanzambi, M Lang - Journal of Thermal Biology, 2022 - Elsevier
Rearing temperature is correlated with the timing and speed of development in a wide range
of poikiloterm animals that do not regulate their body temperature. However, exceptions …
of poikiloterm animals that do not regulate their body temperature. However, exceptions …
Analysis of genetic and protein interactions associated with mutant Huntingtin-induced degeneration
R Spicer - 2024 - orca.cardiff.ac.uk
FoxP1 and Mef2C are two genes important for mouse striatal development, the brain region
that is most vulnerable the effects of the mutated protein responsible for Huntington's …
that is most vulnerable the effects of the mutated protein responsible for Huntington's …