Pharmacological properties of chalcones: a review of preclinical including molecular mechanisms and clinical evidence

B Salehi, C Quispe, I Chamkhi, N El Omari… - Frontiers in …, 2021 - frontiersin.org
Chalcones are among the leading bioactive flavonoids with a therapeutic potential
implicated to an array of bioactivities investigated by a series of preclinical and clinical …

Chalcone: a promising bioactive scaffold in medicinal chemistry

G Rajendran, D Bhanu, B Aruchamy, P Ramani… - Pharmaceuticals, 2022 - mdpi.com
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …

Rational design of comb-shaped poly (arylene indole piperidinium) to enhance hydroxide ion transport for H2/O2 fuel cell

X Zhou, L Wu, G Zhang, R Li, X Hu, X Chang… - Journal of Membrane …, 2021 - Elsevier
To produce anion exchange membranes (AEMs) possessing high conductivity and chemical
stability, we propose a ternary copolymerization strategy to prepare comb-shaped poly …

Recent accomplishments on the synthetic/biological facets of pharmacologically active 1H-1, 2, 3-triazoles

S Kumar, B Sharma, V Mehra, V Kumar - European Journal of Medicinal …, 2021 - Elsevier
The continuous demand of medicinally important scaffolds has prompted the synthetic
chemists to identify simple and efficient routes for their synthesis. 1H-1, 2, 3-triazole …

Ferrocene-based compounds with antimalaria/anticancer activity

S Peter, BA Aderibigbe - Molecules, 2019 - mdpi.com
Malaria and cancer are chronic diseases. The challenge with drugs available for the
treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent …

Ferrocene-appended pharmacophores: An exciting approach for modulating the biological potential of organic scaffolds

A Singh, I Lumb, V Mehra, V Kumar - Dalton transactions, 2019 - pubs.rsc.org
Two exemplary contributions of organometallics in medicinal chemistry, ferroquine and
ferrocifen, which exhibit excellent anti-plasmodial and anti-cancer activities, respectively …

Ferrocene derivatives as anti-infective agents

BS Ludwig, JDG Correia, FE Kühn - Coordination Chemistry Reviews, 2019 - Elsevier
Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …

Development of novel isatin–nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing–bacteria

ZM Elsayed, WM Eldehna, MM Abdel-Aziz… - Journal of enzyme …, 2021 - Taylor & Francis
Joining the global fight against Tuberculosis, the world's most deadly infectious disease,
herein we present the design and synthesis of novel isatin-nicotinohydrazide hybrids (5a–m …

Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition

MM Amin, GEDA Abuo-Rahma, MSA Shaykoon… - Bioorganic …, 2023 - Elsevier
The present study established thirteen novel 8-hydroxyquinoline/chalcone hybrids 3a–m of
hopeful anticancer activity. According to NCI screening and MTT assay results, compounds …

Synthesis, antimalarial and antioxidant activity of coumarin appended 1, 4-disubstituted 1, 2, 3-triazoles

CP Kaushik, M Chahal - Monatshefte für Chemie-Chemical Monthly, 2021 - Springer
A series of coumarin appended triazole hybrids of biotic interest was synthesized through
click chemistry approach from the coumarin based terminal alkynes and aromatic azides. All …