Malaria continues to be one of the most devastating diseases impacting global health.
Although there have been significant reductions in global malaria incidence and mortality …

Bioanalytical processes such as ligand-binding assays, nucleic acid amplification tests and
cancer cell identification methods require multiple steps including sampling, transport …

Nucleic acid-based diagnostic tests often require isolation and concentration of nucleic
acids from biological samples. Commercial purification kits are difficult to use in low …

3D-printed laboratory devices can enable ambitious research purposes even at a low-
budget level. To follow this trend, here we describe the construction, calibration, and usage …

Synthetic oligonucleotides have become a fundamental tool in a wide range of biological
fields, including synthetic biology, biosensing, and DNA storage. Reliable access to …

Metastasis is often critical to cancer progression and linked to poor survival and drug
resistance. Early detection of metastasis, as well as identification of metastatic tumor sites …

Nucleic acids are often covalently modified with fluorescent reporter molecules to create a
hybridization state-dependent optical signal. Designing such a nucleic acid reporter involves …

The development of the first open-source automated peptide synthesizer, PepSy, using
Arduino UNO and readily available components is reported. PepSy was primarily designed …

SETTING: Eliminating tuberculosis in high-burden settings requires improved diagnostic
capacity. Important tests such as Xpert® MTB/RIF and culture are often performed at …

Magnetic beads are a popular method for concentrating biomolecules from solution and
have been more recently used in multistep pre-arrayed microfluidic cartridges. Typical …