FOXM1 and cancer: faulty cellular signaling derails homeostasis

D Kalathil, S John, AS Nair - Frontiers in oncology, 2021 - frontiersin.org
Forkhead box transcription factor, FOXM1 is implicated in several cellular processes such as
proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue …

FOXM1: From cancer initiation to progression and treatment

CY Koo, KW Muir, EWF Lam - Biochimica et Biophysica Acta (BBA)-Gene …, 2012 - Elsevier
The Forkhead box protein M1 (FOXM1) transcription factor is a regulator of myriad biological
processes, including cell proliferation, cell cycle progression, cell differentiation, DNA …

A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets

DS Castro, B Martynoga, C Parras… - Genes & …, 2011 - genesdev.cshlp.org
Proneural genes such as Ascl1 are known to promote cell cycle exit and neuronal
differentiation when expressed in neural progenitor cells. The mechanisms by which …

FOXM1: A small fox that makes more tracks for cancer progression and metastasis

MA Khan, P Khan, A Ahmad, M Fatima… - Seminars in Cancer …, 2023 - Elsevier
Transcription factors (TFs) are indispensable for the modulation of various signaling
pathways associated with normal cell homeostasis and disease conditions. Among cancer …

FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression

J Cui, M Shi, D Xie, D Wei, Z Jia, S Zheng, Y Gao… - Clinical Cancer …, 2014 - AACR
Abstract Purpose: The transcription factor Forkhead box protein M1 (FOXM1) plays critical
roles in cancer development and progression. However, the regulatory role and underlying …

FOXM1 promotes hepatocellular carcinoma progression by regulating KIF4A expression

G Hu, Z Yan, C Zhang, M Cheng, Y Yan… - Journal of Experimental …, 2019 - Springer
Abstract Background Forkhead box M1 (FOXM1) is a proliferation-associated transcription
factor of the forkhead box proteins superfamily, which includes four isoforms FOXM1a, b, c …

FOX (M1) news—it is cancer

M Halasi, AL Gartel - Molecular cancer therapeutics, 2013 - AACR
FOXM1 is an oncogenic transcription factor of the Forkhead family and it has a well-defined
role in cell proliferation and cell-cycle progression. Expression of FOXM1 is excluded in …

A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer

M Shi, J Cui, J Du, D Wei, Z Jia, J Zhang, Z Zhu… - Clinical Cancer …, 2014 - AACR
Purpose: Krüppel-like factor 4 (KLF4) is a transcription factor and putative tumor suppressor.
However, little is known about its effect on aerobic glycolysis in pancreatic tumors …

MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells

K Joshi, Y Banasavadi-Siddegowda, X Mo, SH Kim… - Stem …, 2013 - academic.oup.com
Glioblastoma multiforme (GBM) is a life-threatening brain tumor. Accumulating evidence
suggests that eradication of glioma stem-like cells (GSCs) in GBM is essential to achieve …

FoxM1 and Wnt/β-catenin signaling in glioma stem cells

A Gong, S Huang - Cancer research, 2012 - AACR
Cancer stem cells may be responsible for tumor initiation and maintenance. The molecular
mechanisms that control cancer stem cells are related to alterations in various signaling …