The cytosol-localised mevalonic acid (MVA) pathway delivers the basic isoprene unit
isopentenyl diphosphate (IPP). In higher plants, this central metabolic intermediate is also …

The combination of synthetic and systems biology is a powerful framework to study
fundamental questions in biology and produce chemicals of immediate practical application …

Isoprenoids, often called terpenoids, are the most abundant and highly diverse family of
natural organic compounds. In plants, they play a distinct role in the form of photosynthetic …

Branched five carbon (C 5) alcohols are attractive targets for microbial production due to
their desirable fuel properties and importance as platform chemicals. In this study, we …

The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …

Sesquiterpenes are a large variety of terpene natural products, widely existing in plants,
fungi, marine organisms, insects, and microbes. Value-added sesquiterpenes are …

Isoprenoids are an attractive class of metabolites for enzymatic synthesis from renewable
substrates. However, metabolic engineering of microorganisms for monoterpenoid …

Monoterpenes (C10 isoprenoids) are the main components of essential oils and are
possible precursors for many commodity chemicals and high energy density fuels …

Successful feeding of the substrate geranylpyrophosphate (GPP) to monoterpene synthase
is critical to the efficient microbial production of monoterpenes. Overexpression of GPP …

Understanding the complex interactions that occur between heterologous and native
biochemical pathways represents a major challenge in metabolic engineering and synthetic …