Cardiovascular diseases (CVDs) are arguably the most important comorbidities in chronic
obstructive pulmonary disease (COPD). CVDs are common in people with COPD, and their …

Telomeres are regions of repetitive nucleotide sequences at the ends of chromosomes.
Telomere length is a marker of DNA damage, which is often considered a biomarker for …

Background A person's rate of aging has important implications for his/her risk of death and
disease; thus, quantifying aging using observable characteristics has important applications …

Regular exercise has multi-system anti-aging effects. Here we summarize how exercise
impacts the major hallmarks of aging. We propose that, besides searching for novel …

Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and
oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during …

Importance Psychological stress contributes to numerous diseases and may do so in part
through damage to telomeres, protective non-coding segments on the ends of …

Background Vascular aging results in stiffer arteries and may have a role in the development
of cardiovascular disease (CVD). Arterial stiffness index (ASI), measured by finger …

Heritability allows a comparison of the relative importance of genes and environment to the
variation of traits within and across populations. The concept of heritability and its definition …

OBJECTIVE: To provide a systematic review of the relationship between age and leukocyte
telomere length (LTL) in adults. METHODS: Relevant studies were identified by a systematic …

Obesity and smoking are important risk factors for many age-related diseases. Both are
states of heightened oxidative stress, which increases the rate of telomere erosion per …