The Journal of Biological Chemistry (JBC) has been a major vehicle for disseminating and
recording the discovery and characterization of proteolytic enzymes. The pace of discovery …

Diabetes is widely recognized as an emerging epidemic that has a cumulative impact on
almost every country, age group, and economy across the world. According to the …

3′, 5′-cyclic adenosine monophosphate (cAMP) dependent protein kinase or protein
kinase A (PKA) has served as a prototype for the large family of protein kinases that are …

RNA interference has tremendous yet unrealized potential to treat a wide range of illnesses.
Innovative solutions are needed to protect and selectively deliver small interfering RNA …

Cisplatin (DDP) is widely used in the treatment of cancer as a chemotherapeutic drug.
However, its severe nephrotoxicity limits the extensive application of cisplatin, which is …

Meprins are membrane‐bound and secreted metalloproteinases consisting of α and/or β
subunits that are highly expressed in kidney epithelial cells and are differentially expressed …

Background Meprin metalloproteases are abundantly expressed in the brush border
membranes of kidney proximal tubules and small intestines. Meprins are also expressed in …

Abstract Monocyte chemotactic protein 1 (CCL2/MCP-1) is a small chemokine involved in
the recruitment and trafficking of mononuclear immune cells to inflammation sites. Our …

Meprin metalloproteinases have been implicated in the pathophysiology of
ischemia/reperfusion (IR)‐induced kidney injury. Previous in vitro data showed that meprin β …

Diabetic foot is one of the most serious complications in patients with diabetes mellitus. It is
distinguished by the development of ulcerations on the sole of the foot. Before the …